Motherboard compatibility is a critical consideration when building or upgrading a computer, as it determines the integration and functionality of various components. Compatibility revolves around several key factors, including form factor, CPU socket type, RAM compatibility, and expansion slots. The form factor must align with the computer case to ensure a proper fit, and different sizes, such as ATX, MicroATX, and Mini-ITX, cater to varying build sizes. The CPU socket type on the motherboard must match the socket type of the chosen processor for proper installation and communication. RAM compatibility involves the supported memory type, speed, and maximum capacity, ensuring optimal performance. Expansion slots, such as PCIe, must align with the requirements of additional components like graphics cards or network adapters. Additionally, connectors for power supply, storage devices (SATA or M.2), and front-panel inputs need to match the motherboard specifications. Thorough understanding of these compatibility aspects is crucial to avoid issues, ensure a smooth build process, and optimize the performance of the computer system.